From Toronto, follow the Queen Elizabeth Way (QEW) toward Niagara. Once across the Garden City Skyway at St Catharines, take the Niagara-on-the-Lake exit (38B). From the traffic light at York Road, The Shaw is signposted - left onto York Road, then right onto Highway 55. Follow 55 (Niagara Stone Road) east until it ends at the golf course. Turn right into downtown Niagara-on-the-Lake. Turn left at King Street and go 1 block to 143 King Street.

From The USA, visitors have several choices. One may cross into Canada from Buffalo, NY to Fort Erie, Ontario via the Peace Bridge or Cross over at the Rainbow Bridge in Niagara Falls, NY and in either case follow the QEW Toronto and exit at Highway 55. Another choice is to cross into Canada at Lewiston NY / Queenston Ontario Bridge and follow the Niagara Parkway directly into Niagara On The Lake.

You can get precise driving instructions  Google Maps.